Propiolic Acid → HCID 22258176, compound

HRID 1610851Notes

Reaction equation

HRID 1610851 reaction equation
[Br:1][C:2]1[N:3]=[C:4]([CH2:7][C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])[NH:5][CH:6]=1.[C:16](O)(=[O:19])[C:17]#[CH:18].N1(C(N2C=CN=C2)=O)C=CN=C1>>[C:8]([C:7]1[CH:18]=[CH:17][C:16](=[O:19])[N:5]2[CH:6]=[C:2]([Br:1])[NH:3][C:4]=12)(=[O:9])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 178520383HCID 178520383, compound

Product 1

HCID 22258176HCID 22258176, compound

Procedure

The compound is prepared as described in example 6 with 96.50 mg (0.36 mmol) of 2-(4-bromo-1H-imidazol-2-yl)-1-phenylethanone (example XXXXIII), 39.84 mg (0.55 mmol) of propiolic acid and 106.24 mg (0.66 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-4c83a744fe8746a497d7dd3a577d8fc1
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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