Propiolic Acid → HCID 22258174, compound

HRID 1610854Notes

Reaction equation

HRID 1610854 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:22])[CH2:10][C:11]1[NH:15][C:14]2[CH2:16][CH:17]([CH3:21])[CH:18]([CH3:20])[CH2:19][C:13]=2[N:12]=1.[C:23](O)(=[O:26])[C:24]#[CH:25].N1(C(N2C=CN=C2)=O)C=CN=C1>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]([C:10]1[CH:25]=[CH:24][C:23](=[O:26])[N:15]2[C:14]3[CH2:16][CH:17]([CH3:21])[CH:18]([CH3:20])[CH2:19][C:13]=3[NH:12][C:11]=12)=[O:22]

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 22258295HCID 22258295, compound

Product 1

HCID 22258174HCID 22258174, compound

Procedure

The compounds are prepared as described in example 15 with 200 mg (0.66 mmol) of 1-(2,4-Difluorophenyl)-2-(5,6-dimethyl-4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone (example XV), 69 mg (0.99 mmol) of propiolic acid and 192 mg (1.18 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole.

Workup

  1. customThe compounds are prepared

Sources & evidence

ORD record
ord-fb0e4630ff45458cb99235ef4ec742e5
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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