Propiolic Acid → HCID 22258216, compound

HRID 1610856Notes

Reaction equation

HRID 1610856 reaction equation
[CH2:1]([C:5]1[N:6]=[C:7]([CH2:11][C:12]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)=[O:13])[NH:8][C:9]=1[CH3:10])[CH2:2][CH2:3][CH3:4].[C:21](O)(=[O:24])[C:22]#[CH:23].N1(C(N2C=CN=C2)=O)C=CN=C1>>[CH2:1]([C:5]1[NH:6][C:7]2[N:8]([C:9]=1[CH3:10])[C:21](=[O:24])[CH:22]=[CH:23][C:11]=2[C:12](=[O:13])[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 22258259HCID 22258259, compound

Product 1

HCID 22258216HCID 22258216, compound

Procedure

The compounds are prepared as described in example 10 with 200 mg (0.73 mmol) of 2-(4-butyl-5-methyl-1H-imidazo-2-yl)-1-(4-fluorophenyl)ethanone (example XXVI), 77 mg (1.09 mmol) of propiolic acid and 212 mg (1.31 mmol) of 1-(1H-imidazol-1-ylcarbonyl)-1H-imidazole.

Workup

  1. customThe compounds are prepared

Sources & evidence

ORD record
ord-7d8a1c84cea64a5badbc7cf75976a3f3
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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