Propiolic Acid → HCID 22258240, compound

HRID 1610858Notes

Reaction equation

HRID 1610858 reaction equation
[CH:1]([C:4]1[N:5]=[C:6]([CH2:9][C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])[NH:7][CH:8]=1)([CH3:3])[CH3:2].[C:18](O)(=[O:21])[C:19]#[CH:20].N1(C(N2C=CN=C2)=O)C=CN=C1>>[C:10]([C:9]1[CH:20]=[CH:19][C:18](=[O:21])[N:7]2[CH:8]=[C:4]([CH:1]([CH3:3])[CH3:2])[NH:5][C:6]=12)(=[O:11])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 10110Propiolic AcidHCID 682631,1'-CarbonyldiimidazoleHCID 178439623HCID 178439623, compound

Product 1

HCID 22258240HCID 22258240, compound

Procedure

The compound is prepared as described in example 15 with 105 mg (0.46 mmol) of 2-(4-isopropyl-1H-imidazol-2-yl)-1-phenylethanone (example X, 48.3 mg (0.69 mmol) of propiolic acid and 134 mg (0.83 mmol) of 1-(1H-imidazol-1-yl-carbonyl)-1H-imidazole.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-48e6c780fd3d4ffa8655adee499e4bd7
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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