Methyl propiolate → HCID 22258179, compound

HRID 1610859Notes

Reaction equation

HRID 1610859 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:21])[CH2:10][C:11]2[NH:15][C:14]3[CH2:16][CH2:17][CH2:18][CH:19]([CH3:20])[C:13]=3[N:12]=2)=[CH:5][CH:4]=1.C[O-].[Na+].[C:25](OC)(=[O:28])[C:26]#[CH:27]>>[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([C:10]2[CH:27]=[CH:26][C:25](=[O:28])[N:15]3[C:14]4[CH2:16][CH2:17][CH2:18][CH:19]([CH3:20])[C:13]=4[NH:12][C:11]=23)=[O:21])=[CH:5][CH:4]=1

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258236HCID 22258236, compound

Product 1

HCID 22258179HCID 22258179, compound

Procedure

The compound is prepared as described in example 20 with 200 mg (0.65 mmol) of 1-(4-fluorophenyl)-2-(4-methyl-4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone hydrochloride (example XVI), 50 mg (0.93 mmol) of sodium methylate and 54.4 mg (0.65 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-14a0f8786b90410b88a3732ec195ef6e
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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