Methyl propiolate → HCID 22258220, compound

HRID 1610865Notes

Reaction equation

HRID 1610865 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:9](=[O:20])[CH2:10][C:11]2[NH:15][C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[N:12]=2)[CH:5]=[CH:6][C:7]=1[F:8].C[O-].[Na+].[C:24](OC)(=[O:27])[C:25]#[CH:26]>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[F:8])[C:9]([C:10]1[CH:26]=[CH:25][C:24](=[O:27])[N:15]2[C:14]3[CH2:16][CH2:17][CH2:18][CH2:19][C:13]=3[NH:12][C:11]=12)=[O:20]

Participants

4

Reactant 3

HCID 13536Methyl propiolateHCID 10942334Sodium MethoxideHCID 22258217HCID 22258217, compound

Product 1

HCID 22258220HCID 22258220, compound

Procedure

The compound is prepared as described in example 20 with 200 mg (0.72 mmol) of 1-(3,4-Difluorophenyl)-2-(4,5,6,7-tetrahydro-1H-benzimidazol-2-yl)ethanone (example XXXVII), 78.2 mg (1.45 mmol) of sodium methylate and 60.9 mg (0.72 mmol) methyl propiolate.

Workup

  1. customThe compound is prepared

Sources & evidence

ORD record
ord-830dc7a57e434efca1347b0fe68d6215
Source dataset
uspto-grants-2006_01
Patent number
US06984646B2

Reaction notes

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