Methyl propiolate → HCID 22258190, compound

HRID 1610880Notes

Reaction equation

Cl.[F:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:23])[CH2:10][C:11]2[NH:12][C:13]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[C:14]([CH3:16])[N:15]=2)=[CH:5][CH:4]=1.C[O-].[Na+].[C:27](OC)(=[O:30])[C:28]#[CH:29]>>[F:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]([C:10]2[CH:29]=[CH:28][C:27](=[O:30])[N:15]3[C:14]([CH3:16])=[C:13]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[NH:12][C:11]=23)=[O:23])=[CH:7][CH:8]=1

Participants

Reactant 3

HCID 13536Methyl propiolate

HCID 10942334Sodium Methoxide

HCID 178432801HCID 178432801, compound

Product 1

HCID 22258190HCID 22258190, compound

Procedure

The compound is prepared as described in example 25 with 300 mg (0.91 mmol) of 1-(4-fluorophenyl)-2-(4-methyl-5-phenyl-1H-imidazol-2-yl)ethanone hydrochloride (example LI), 90 mg (1.80 mmol) of sodium methylate and 76 mg (0.91 mmol) methyl propiolate.

Workup

customThe compound is prepared

Sources & evidence

ORD record: ord-72db465e63fc4c61862c8054010d4282
Source dataset: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06984646B2

Reaction notes

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