1,3-Dichloroacetone → HCID 22259331, compound

HRID 1610953Notes

Reaction equation

HRID 1610953 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]([NH2:12])=[O:11])=[CH:4][C:3]=1[F:13].[Cl:14][CH2:15][C:16]([CH2:18]Cl)=O>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[O:11][CH:18]=[C:16]([CH2:15][Cl:14])[N:12]=2)=[CH:4][C:3]=1[F:13]

Participants

3

Reactant 2

HCID 107931,3-DichloroacetoneHCID 22259286HCID 22259286, compound

Product 1

HCID 22259331HCID 22259331, compoundYield 41.9%

Procedure

Using (E)-3-(4-chloro-3-fluorophenyl)-2-propenamide (8.67 g) and 1,3-dichloroacetone (11.0 g), the same reaction as Reference Example 1-(ii) was carried out to yield the titled compound (4.95 g) as colorless flaky crystals.

Workup

  1. customthe same reaction as Reference Example 1-(ii)

Sources & evidence

ORD record
ord-2ecf40f2f4e449c2bb3a6293d80ae2b2
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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