Methanesulfonyl chloride → HCID 22259356, compound

HRID 1610971Notes

Reaction equation

HRID 1610971 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:8]=[CH:7][C:6](/[CH:9]=[CH:10]/[C:11]2[O:12][CH:13]=[C:14]([CH2:16][O:17][C:18]3[CH:23]=[CH:22][C:21]([CH2:24][CH2:25][CH2:26][CH2:27][N:28]4[CH:32]=[CH:31][N:30]=[C:29]4[CH2:33][CH2:34]O)=[CH:20][CH:19]=3)[N:15]=2)=[CH:5][CH:4]=1.[CH3:38][S:39](Cl)(=O)=O.C[S-].[Na+]>C(N(CC)CC)C>[CH3:38][S:39][CH2:34][CH2:33][C:29]1[N:28]([CH2:27][CH2:26][CH2:25][CH2:24][C:21]2[CH:22]=[CH:23][C:18]([O:17][CH2:16][C:14]3[N:15]=[C:11](/[CH:10]=[CH:9]/[C:6]4[CH:7]=[CH:8][C:3]([C:2]([F:37])([F:36])[F:1])=[CH:4][CH:5]=4)[O:12][CH:13]=3)=[CH:19][CH:20]=2)[CH:32]=[CH:31][N:30]=1

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 4378561Sodium methanethiolateHCID 22259324HCID 22259324, compound

Product 1

HCID 22259356HCID 22259356, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Using 2-[1-[4-[4-[[2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazol-4-yl]methoxy]phenyl]butyl]-1H-imidazol-2-yl]-1-ethanol (1.00 g), triethylamine (0.544 ml), methanesulfonyl chloride (0.182 ml) and sodium thiomethoxide (288 mg), the same reaction as Reference Example 6-(iii) was carried out to yield the titled compound (761 mg) as a colorless amorphous form.

Workup

  1. customthe same reaction as Reference Example

Sources & evidence

ORD record
ord-95fb0eb2672241ed90e79136b20bdef7
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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