m-Chloroperbenzoic acid → HCID 22259316, compound

HRID 1610972Notes

Reaction equation

HRID 1610972 reaction equation
[CH3:1][S:2][CH2:3][CH2:4][C:5]1[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:38]=[CH:37][C:17]([O:18][CH2:19][C:20]3[N:21]=[C:22](/[CH:25]=[CH:26]/[C:27]4[CH:32]=[CH:31][C:30]([C:33]([F:36])([F:35])[F:34])=[CH:29][CH:28]=4)[O:23][CH:24]=3)=[CH:16][CH:15]=2)[CH:7]=[CH:8][N:9]=1.ClC1C=CC=C(C(OO)=[O:47])C=1>>[CH3:1][S:2]([CH2:3][CH2:4][C:5]1[N:6]([CH2:10][CH2:11][CH2:12][CH2:13][C:14]2[CH:38]=[CH:37][C:17]([O:18][CH2:19][C:20]3[N:21]=[C:22](/[CH:25]=[CH:26]/[C:27]4[CH:32]=[CH:31][C:30]([C:33]([F:35])([F:34])[F:36])=[CH:29][CH:28]=4)[O:23][CH:24]=3)=[CH:16][CH:15]=2)[CH:7]=[CH:8][N:9]=1)=[O:47]

Participants

3

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 22259356HCID 22259356, compound

Product 1

HCID 22259316HCID 22259316, compoundYield 73.8%

Procedure

Using 4-[[4-[4-[2-[2-(methylsulfanyl)ethyl]-1H-imidazol-1-yl]butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole (250 mg) and 70% m-chloroperbenzoic acid (114 mg), the same reaction as Example 11-(ii) was carried out to yield the titled compound (190 mg) as a colorless amorphous form.

Workup

  1. customthe same reaction as Example 11-(ii)

Sources & evidence

ORD record
ord-5e22aca0588f4801bd9516b802d1468e
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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