Sodium hydride → HCID 22259287, compound

HRID 1610978Notes

Reaction equation

HRID 1610978 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][CH:11]=2)[O:6][CH:7]=1.[CH3:17][S:18]([CH2:21][C:22]1[N:23]([CH2:27][CH2:28][CH2:29][CH2:30][C:31]2[CH:36]=[CH:35][C:34]([OH:37])=[CH:33][CH:32]=2)[CH:24]=[CH:25][N:26]=1)(=[O:20])=[O:19].[H-].[Na+]>>[Cl:16][C:13]1[CH:14]=[CH:15][C:10](/[CH:9]=[CH:8]/[C:5]2[O:6][CH:7]=[C:3]([CH2:2][O:37][C:34]3[CH:33]=[CH:32][C:31]([CH2:30][CH2:29][CH2:28][CH2:27][N:23]4[CH:24]=[CH:25][N:26]=[C:22]4[CH2:21][S:18]([CH3:17])(=[O:20])=[O:19])=[CH:36][CH:35]=3)[N:4]=2)=[CH:11][CH:12]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 22242094HCID 22242094, compoundHCID 222592974-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol

Product 1

HCID 22259287HCID 22259287, compoundYield 75.5%

Procedure

Using 4-(chloromethyl)-2-[(E)-2-(4-chlorophenyl)ethenyl]-1,3-oxazole (227 mg), 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol (250 mg) and 65% sodium hydride (32.9 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (322 mg) as a colorless crystal powder.

Workup

  1. customthe same reaction as Example 11-(i)

Sources & evidence

ORD record
ord-82da29c955534448b4e9e4b82744b9f7
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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