Sodium hydride → HCID 22259306, compound

HRID 1610981Notes

Reaction equation

HRID 1610981 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[O:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=2)=[C:4]([F:17])[CH:3]=1.[CH3:18][S:19]([CH2:22][C:23]1[N:24]([CH2:28][CH2:29][CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=2)[CH:25]=[CH:26][N:27]=1)(=[O:21])=[O:20].[H-].[Na+]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[O:11][CH:12]=[C:13]([CH2:15][O:38][C:35]3[CH:34]=[CH:33][C:32]([CH2:31][CH2:30][CH2:29][CH2:28][N:24]4[CH:25]=[CH:26][N:27]=[C:23]4[CH2:22][S:19]([CH3:18])(=[O:21])=[O:20])=[CH:37][CH:36]=3)[N:14]=2)=[C:4]([F:17])[CH:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 22242081HCID 22242081, compoundHCID 222592974-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol

Product 1

HCID 22259306HCID 22259306, compoundYield 23.8%

Procedure

Using 2-[(E)-2-(4-chloro-2-fluorophenyl)ethenyl]-4-(chloromethyl)-1,3-oxazole (243 mg), 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol (250 mg) and 65% sodium hydride (35.9 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (105 mg) as a colorless crystal powder.

Workup

  1. customthe same reaction as Example 11-(i)

Sources & evidence

ORD record
ord-2f5ea1df345e4a408374c1dfa469645a
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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