Sodium hydride → HCID 22259349, compound

HRID 1610983Notes

Reaction equation

HRID 1610983 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[O:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=2)=[C:4]([F:17])[CH:3]=1.[CH3:18][S:19]([CH2:22][C:23]1[N:24]([CH2:28][CH2:29][CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=2)[CH:25]=[CH:26][N:27]=1)(=[O:21])=[O:20].[H-].[Na+]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5](/[CH:8]=[CH:9]/[C:10]2[O:11][CH:12]=[C:13]([CH2:15][O:38][C:35]3[CH:34]=[CH:33][C:32]([CH2:31][CH2:30][CH2:29][CH2:28][N:24]4[CH:25]=[CH:26][N:27]=[C:23]4[CH2:22][S:19]([CH3:18])(=[O:21])=[O:20])=[CH:37][CH:36]=3)[N:14]=2)=[C:4]([F:17])[CH:3]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 222592974-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenolHCID 22259310HCID 22259310, compound

Product 1

HCID 22259349HCID 22259349, compoundYield 65.6%

Procedure

Using 2-[(E)-2-(4-bromo-2-fluorophenyl)ethenyl]-4-(chloromethyl)-1,3-oxazole (282 mg), 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol (250 mg) and 65% sodium hydride (32.9 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (313 mg) as a colorless crystal powder.

Workup

  1. customthe same reaction as Example 11-(i)

Sources & evidence

ORD record
ord-c946dccc554444628b19e66a69937dfb
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

Loading…