Sodium hydride → HCID 22259296, compound

HRID 1610984Notes

Reaction equation

HRID 1610984 reaction equation
Cl[CH2:2][C:3]1[N:4]=[C:5](/[CH:8]=[CH:9]/[C:10]2[CH:15]=[CH:14][C:13]([F:16])=[C:12]([F:17])[CH:11]=2)[O:6][CH:7]=1.[CH3:18][S:19]([CH2:22][C:23]1[N:24]([CH2:28][CH2:29][CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=2)[CH:25]=[CH:26][N:27]=1)(=[O:21])=[O:20].[H-].[Na+]>>[F:17][C:12]1[CH:11]=[C:10](/[CH:9]=[CH:8]/[C:5]2[O:6][CH:7]=[C:3]([CH2:2][O:38][C:35]3[CH:34]=[CH:33][C:32]([CH2:31][CH2:30][CH2:29][CH2:28][N:24]4[CH:25]=[CH:26][N:27]=[C:23]4[CH2:22][S:19]([CH3:18])(=[O:21])=[O:20])=[CH:37][CH:36]=3)[N:4]=2)[CH:15]=[CH:14][C:13]=1[F:16]

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 22259288HCID 22259288, compoundHCID 222592974-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol

Product 1

HCID 22259296HCID 22259296, compoundYield 61%

Procedure

Using 4-(chloromethyl)-2-[(E)-2-(3,4-difluorophenyl)ethenyl]-1,3-oxazole (228 mg), 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol (250 mg) and 65% sodium hydride (32.9 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (261 mg) as colorless flaky crystals.

Workup

  1. customthe same reaction as Example 11-(i)

Sources & evidence

ORD record
ord-66ab5e5ef39b4ef7ac441532a774150b
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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