Sodium hydride → HCID 22259319, compound

HRID 1610985Notes

Reaction equation

HRID 1610985 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]1[O:12][CH:13]=[C:14]([CH2:16]Cl)[N:15]=1.[CH3:18][S:19]([CH2:22][C:23]1[N:24]([CH2:28][CH2:29][CH2:30][CH2:31][C:32]2[CH:37]=[CH:36][C:35]([OH:38])=[CH:34][CH:33]=2)[CH:25]=[CH:26][N:27]=1)(=[O:21])=[O:20].[H-].[Na+]>>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1/[CH:9]=[CH:10]/[C:11]1[O:12][CH:13]=[C:14]([CH2:16][O:38][C:35]2[CH:34]=[CH:33][C:32]([CH2:31][CH2:30][CH2:29][CH2:28][N:24]3[CH:25]=[CH:26][N:27]=[C:23]3[CH2:22][S:19]([CH3:18])(=[O:21])=[O:20])=[CH:37][CH:36]=2)[N:15]=1

Participants

4

Reactant 3

HCID 24758Sodium hydrideHCID 222592974-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenolHCID 22259350HCID 22259350, compound

Product 1

HCID 22259319HCID 22259319, compoundYield 68.9%

Procedure

Using 2-[(E)-2-(2-chloro-4-fluorophenyl)ethenyl]-4-(chloromethyl)-1,3-oxazole (243 mg), 4-[4-[2-[(methylsulfonyl)methyl]-1H-imidazol-1-yl]butyl]phenol (250 mg) and 65% sodium hydride (32.9 mg), the same reaction as Example 11-(i) was carried out to yield the titled compound (304 mg) as colorless needle crystals.

Workup

  1. customthe same reaction as Example 11-(i)

Sources & evidence

ORD record
ord-e9fcc4fb37ec431ba677874857a0d2c3
Source dataset
uspto-grants-2006_01
Patent number
US06984653B2

Reaction notes

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