反应详情

LiBu is added to the solution in THF and hexane of 4,7-dimethyl-indene. After 2 hours, the bromide dissolved in 20 ml of THF and 10 ml of hexane is added, at −70° C. The mixture is left to rise to room temperature, after 8 hours water is added and the mixture is extracted with ethyl ether. After washing the organic extracts to neutrality and anhydrifying on Na2SO4, the solvent is evaporated. 3.1 g of product are obtained, after purification on a silica gel column using hexane/ethyl acetate as eluant in a ratio of 98/2 (yield=31%).

1. waitThe mixture is left
2. waitto rise to room temperature, after 8 hours
3. extractionthe mixture is extracted with ethyl ether
4. washAfter washing the organic extracts to neutrality
5. customthe solvent is evaporated