Tetrahydrofuran → 4-(4-Chloromethyl-2,6-dimethoxyphenoxymethyl)-5-methyl-2-phenyloxazole

HRID 161117Notes

Reaction equation

HRID 161117 reaction equation
[CH3:5][O:6][c:7]1[cH:8][c:9]([CH2:10][OH:11])[cH:12][c:13]([O:29][CH3:30])[c:14]1[O:15][CH2:16][c:17]1[n:18][c:19](-[c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[o:20][c:21]1[CH3:22].[O:31]1[CH2:32][CH2:33][CH2:34][CH2:35]1.[S:1]([Cl:2])([Cl:3])=[O:4]>>[Cl:3][CH2:10][c:9]1[cH:8][c:7]([O:6][CH3:5])[c:14]([O:15][CH2:16][c:17]2[n:18][c:19](-[c:23]3[cH:24][cH:25][cH:26][cH:27][cH:28]3)[o:20][c:21]2[CH3:22])[c:13]([O:29][CH3:30])[cH:12]1

Participants

4

Reactant 3

HCID 8028TetrahydrofuranHCID 24386Thionyl ChlorideHCID 536741583,5-Dimethoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)benzyl alcohol

Product 1

HCID 223446054-(4-Chloromethyl-2,6-dimethoxyphenoxymethyl)-5-methyl-2-phenyloxazole

Sources & evidence

ORD record
ord-14809cbf94054a93a8ed7277d2051bb6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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