Hydrochloric Acid → HCID 136342442, compound

HRID 1611172Notes

Reaction equation

HRID 1611172 reaction equation
[NH2:1][C:2]1[C:7]([CH2:8][OH:9])=[C:6]([C:10]2[CH2:11][N:12](C(OC(C)(C)C)=O)[CH2:13][CH2:14][CH:15]=2)[CH:5]=[C:4]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[O:29]CC2C=CC(OC)=CC=2)[N:3]=1.[ClH:39]>O1CCOCC1>[ClH:39].[NH2:1][C:2]1[N:3]=[C:4]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=2[OH:29])[CH:5]=[C:6]([C:10]2[CH2:11][NH:12][CH2:13][CH2:14][CH:15]=2)[C:7]=1[CH2:8][OH:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22258933HCID 22258933, compound

Product 1

HCID 136342442HCID 136342442, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

tert-butyl 2′-amino-3′-(hydroxymethyl)-6′-{2-[(4-methoxybenzyl)oxy]phenyl}-5,6-dihydro-3,4′-bipyridine-1(2H)-carboxylate (25.0 mg, 0.05 mmol) was treated with 2N HCl in dioxane (4.0 mL) overnight at room temperature. The resulting solid was collected by filtration, washed with ether and dried under reduced pressure to give 2-[6′-amino-5′-(hydroxymethyl)-1,2,5,6-tetrahydro-3,4′-bipyridin-2′-yl]phenol hydrochloride. (14 mg, yield 87%)

Workup

  1. filtrationThe resulting solid was collected by filtration
  2. washwashed with ether
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-bdeff0ccedc540b1866ffa11d22f672a
Source dataset
uspto-grants-2006_01
Patent number
US06984649B1

Reaction notes

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