Benzene, (2-chloroethoxy)- → HCID 23694330, compound

HRID 1611229Notes

Reaction equation

HRID 1611229 reaction equation
[O-:1][S:2]([O-:4])=[O:3].[Na+:5].[Na+].Cl[CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[O:10]([CH2:9][CH2:8][S:2]([O-:4])(=[O:1])=[O:3])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[Na+:5]

Participants

4

Reactant 2

HCID 12156Benzene, (2-chloroethoxy)-HCID 24437Sodium Sulfite

Product 1

HCID 23694330HCID 23694330, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
120 °C

Procedure

To a solution of Na2SO3 (12.9 g, 102.3 mmol) in 100 mL of water is added β-chlorophenetole (15.3 g, 97.4 mmol), and the mixture is stirred at 120° C. for 24 h. Cooling the mixture affords white precipitates, which are collected by filtration and dried in vacuo. The product is obtained as a white solid in 87% yield. The structure is confirmed by 1H-NMR spectrum (DMSO-d6). δ [ppm]: 2.88 (t, 2H), 4.18 (t, 2H), 6.88-6.93 (m, 3H), 7.24-7.29 (m, 2H).

Workup

  1. temperatureCooling the mixture
  2. customaffords white precipitates, which
  3. filtrationare collected by filtration
  4. customdried in vacuo
  5. customThe product is obtained as a white solid in 87% yield

Sources & evidence

ORD record
ord-37d2a11c6d3343febf38bbf325aa14e9
Source dataset
uspto-grants-2006_01
Patent number
US06986981B2

Reaction notes

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