Triethylamine → Ssr-180711

HRID 1611238Notes

Reaction equation

HRID 1611238 reaction equation
[N:1]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[NH:4][CH2:3][CH2:2]2.C(N(CC)CC)C.Cl[C:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=1)=[O:19]>ClCCl>[N:1]12[CH2:9][CH2:8][CH:5]([CH2:6][CH2:7]1)[N:4]([C:18]([O:20][C:21]1[CH:26]=[CH:25][C:24]([Br:27])=[CH:23][CH:22]=1)=[O:19])[CH2:3][CH2:2]2

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 3984071,4-Diazabicyclo(3.2.2)nonaneHCID 52377364-Bromophenyl chloroformate

Product 1

HCID 9797360Ssr-180711

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Conditions

Temperature
0 °C

Procedure

0.379 g (3.0 mmol) of 1,4-diazabicyclo[3.2.2]nonane and 0.84 ml (6.0 mmol) of triethylamine in 5 ml of dichloromethane are introduced into a 50-ml three-necked flask, the mixture is cooled to 0° C., 0.730 mg (3.1 mmol) of 4-bromophenyl chloroformate in solution in 3 ml of dichloromethane is added dropwise and the stirring is maintained at 0° C. for 10 min.

Workup

  1. temperaturethe stirring is maintained at 0° C. for 10 min.

Sources & evidence

ORD record
ord-8d2c8fa26d724ab3b23780235a06e1f5
Source dataset
uspto-grants-2006_01
Patent number
US06987106B1

Reaction notes

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