(2-Oxopropyl)amine → HCID 86587583, compound

HRID 1611251Notes

Reaction equation

HRID 1611251 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]([N:5]1[CH2:12][CH2:11][CH2:10][C@H:6]1[C:7](Cl)=[O:8])=[O:4].[NH2:15][CH2:16][C:17](=[O:19])[CH3:18]>C(Cl)Cl.N1C=CC=CC=1>[O:19]=[C:17]([CH3:18])[CH2:16][NH:15][C:7]([CH:6]1[CH2:10][CH2:11][CH2:12][N:5]1[C:3](=[O:4])[C:2]([F:14])([F:13])[F:1])=[O:8]

Participants

5

Reactant 2

HCID 215(2-Oxopropyl)amineHCID 3082449N-Trifluoroacetylprolyl chloride

Product 1

HCID 86587583HCID 86587583, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent

Procedure

A solution of (S)-N-(trifluoroacetyl)prolyl chloride (Aldrich) 1 equiv. in DCM is treated with 1-amino-propan-2-one (1.5 equiv.) in pyridine at rt for 5 hours. After usual work up, it provides 1-trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide.

Sources & evidence

ORD record
ord-67e9145e0ea94a6bbb270e07c82db953
Source dataset
uspto-grants-2006_01
Patent number
US06987104B2

Reaction notes

Loading…