HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Oxopropyl)amine → HCID 86587583, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Oxopropyl)amine | HCID 215 | — |
| Reactant | N-Trifluoroacetylprolyl chloride | HCID 3082449 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 86587583 | HCID 86587583 | — |
Reaction Steps
A solution of (S)-N-(trifluoroacetyl)prolyl chloride (Aldrich) 1 equiv. in DCM is treated with 1-amino-propan-2-one (1.5 equiv.) in pyridine at rt for 5 hours. After usual work up, it provides 1-trifluoroacetyl-pyrrolidine-2-carboxylic acid (2-oxo-propyl)-amide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06987104B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-67e9145e0ea94a6bbb270e07c82db953 |
| Source note | uspto-grants-2006_01 |