Bromomethylcyclopropane → HCID 483498, compound

HRID 1611258Notes

Reaction equation

HRID 1611258 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].Br[CH2:21][CH:22]1[CH2:24][CH2:23]1>>[CH:22]1([CH2:21][N:7]2[C:8]([O:9][C:10]3[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=3)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]2=[O:18])[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 483498HCID 483498, compoundYield 46.4%

Procedure

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and bromomethyl cyclopropane were reacted by the same way with the example 1 to obtain the titled compound (146 mg, yield: 46.4%).

Sources & evidence

ORD record
ord-31d39397850f4c1f9010226d7d272688
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

Loading…