Bromomethylcyclopropane → HCID 9883904, compound

HRID 1611259Notes

Reaction equation

HRID 1611259 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[O:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Br[CH2:22][CH:23]1[CH2:25][CH2:24]1>>[CH:23]1([CH2:22][N:8]2[C:9]([O:10][C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]2=[O:19])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 81503BromomethylcyclopropaneHCID 222565785-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 9883904HCID 9883904, compoundYield 40.2%

Procedure

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and bromomethyl cyclopropane were reacted by the same way with the example 1 to obtain the titled compound (132 mg, yield: 40.2%).

Sources & evidence

ORD record
ord-79ac22eb95ae4c5aa563046fb3f52506
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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