Cyclobutylmethyl 4-methylbenzenesulfonate → 1-(Cyclobutyl)methyl-5-isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione

HRID 1611266Notes

Reaction equation

HRID 1611266 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].C1(C)C=CC(S(O[CH2:32][CH:33]2[CH2:36][CH2:35][CH2:34]2)(=O)=O)=CC=1>>[CH:33]1([CH2:32][N:8]2[C:9]([C:10](=[O:19])[C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]2=[O:20])[CH2:36][CH2:35][CH2:34]1

Participants

3

Reactant 2

HCID 13163931Cyclobutylmethyl 4-methylbenzenesulfonateHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159577041-(Cyclobutyl)methyl-5-isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedioneYield 1.3%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and (cyclobutyl)methyl para-toluenesulfonate were reacted by the same way ith the example 1 to obtain the titled compound (182 mg, yield: 1.3%).

Sources & evidence

ORD record
ord-602101b4adea4de7881b5ef8fc77e43d
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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