1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

HRID 1611284Notes

Reaction equation

HRID 1611284 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[S:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[F:21][C:22]([F:33])([F:32])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28]Br)=[CH:26][CH:25]=1>>[F:21][C:22]([F:32])([F:33])[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH2:28][N:8]2[C:9]([S:10][C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]2=[O:19])=[CH:26][CH:25]=1

Participants

3

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 104937275-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

Product 1

HCID 159577161-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneYield 44.8%

Procedure

5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 4-trifluoromethoxybenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (208 mg, yield: 44.8%).

Sources & evidence

ORD record
ord-db6a6c5930de4264bdc89286594c82dc
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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