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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611284Generated: October 30, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611284

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
Reactant5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 10493727—
Product1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneHCID 1595771644.8%

Reaction Steps

5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 4-trifluoromethoxybenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (208 mg, yield: 44.8%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-db6a6c5930de4264bdc89286594c82dc
Source noteuspto-grants-2006_01