1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedione

HRID 1611288Notes

Reaction equation

HRID 1611288 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[F:22][C:23]([F:34])([F:33])[O:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29]Br)=[CH:27][CH:26]=1>>[F:22][C:23]([F:33])([F:34])[O:24][C:25]1[CH:32]=[CH:31][C:28]([CH2:29][N:8]2[C:9]([C:10](=[O:19])[C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]2=[O:20])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 1427851-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159577201-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedioneYield 66%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 4-trifluoromethoxybenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (304 mg, yield: 66.0%).

Sources & evidence

ORD record
ord-eae7817ea0b84328b6155cf30faa79b6
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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