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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611288Generated: November 1, 2026

1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedione

https://huagongshe.com/reaction/1611288

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-(Bromomethyl)-4-(trifluoromethoxy)benzeneHCID 142785—
Reactant6-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dioneHCID 22256582—
Product1-(4-Trifluoromethoxybenzyl)-5-isopropyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedioneHCID 1595772066%

Reaction Steps

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 4-trifluoromethoxybenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (304 mg, yield: 66.0%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-eae7817ea0b84328b6155cf30faa79b6
Source noteuspto-grants-2006_01