2-(Bromomethyl)benzonitrile → 1-(2-Cyanobenzyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 1611290Notes

Reaction equation

HRID 1611290 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[C:20]([C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24]Br)#[N:21]>>[C:20]([C:22]1[CH:29]=[CH:28][CH:27]=[CH:26][C:23]=1[CH2:24][N:7]1[C:8]([O:9][C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]1=[O:18])#[N:21]

Participants

3

Reactant 2

HCID 895992-(Bromomethyl)benzonitrileHCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159577231-(2-Cyanobenzyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneYield 53.5%

Procedure

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2-cyanobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (201 mg, yield: 53.5%).

Sources & evidence

ORD record
ord-90c7724146ef4b0fb44450a1cfdc8500
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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