2-(Bromomethyl)benzonitrile → 1-(2-Cyanobenzyl)-5-isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione

HRID 1611293Notes

Reaction equation

HRID 1611293 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[C:22]([C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26]Br)#[N:23]>>[C:22]([C:24]1[CH:31]=[CH:30][CH:29]=[CH:28][C:25]=1[CH2:26][N:8]1[C:9]([C:10](=[O:19])[C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]1=[O:20])#[N:23]

Participants

3

Reactant 2

HCID 895992-(Bromomethyl)benzonitrileHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159577261-(2-Cyanobenzyl)-5-isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedioneYield 57.5%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2-cyanobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (231 mg, yield: 57.5%).

Sources & evidence

ORD record
ord-043088947c934903b1d66708d3f7c715
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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