3,5-Bis(trifluoromethyl)benzyl bromide → 1-[3,5-Bis(trifluoromethyl)benzyl]-5-ethyl-6-(3,5-dimethyl-phenyl)thio-2,4-pyrimidinedione

HRID 1611312Notes

Reaction equation

HRID 1611312 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[S:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[F:20][C:21]([F:35])([F:34])[C:22]1[CH:23]=[C:24]([CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1)[CH2:25]Br>>[F:20][C:21]([F:34])([F:35])[C:22]1[CH:23]=[C:24]([CH:27]=[C:28]([C:30]([F:33])([F:31])[F:32])[CH:29]=1)[CH2:25][N:7]1[C:8]([S:9][C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]1=[O:18]

Participants

3

Reactant 2

HCID 1225733,5-Bis(trifluoromethyl)benzyl bromideHCID 104927276-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159577421-[3,5-Bis(trifluoromethyl)benzyl]-5-ethyl-6-(3,5-dimethyl-phenyl)thio-2,4-pyrimidinedioneYield 45%

Procedure

5-Ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 3,5-bis(trifluoromethyl)benzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (226 mg, yield: 45.0%).

Sources & evidence

ORD record
ord-07ddda38b5a84ddfa44f29d6b4e70a07
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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