2-(Bromomethyl)-1,4-difluorobenzene → 1-(2,5-Difluorobenzyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 1611320Notes

Reaction equation

HRID 1611320 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[F:20][C:21]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=1[CH2:23]Br>>[F:20][C:21]1[CH:28]=[CH:27][C:26]([F:29])=[CH:25][C:22]=1[CH2:23][N:7]1[C:8]([O:9][C:10]2[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=2)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]1=[O:18]

Participants

3

Reactant 2

HCID 5228302-(Bromomethyl)-1,4-difluorobenzeneHCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159577491-(2,5-Difluorobenzyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneYield 47.9%

Procedure

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2,5-difluorobenzyl bromide were reacted by the same way with the example 1 to obtain the titled compound (185 mg, yield: 47.9%).

Sources & evidence

ORD record
ord-e1f4e1b09ae64349b3cbcaedc2d1f8c9
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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