2-(Chloromethyl)anthraquinone → 6-(3,5-Dimethylphenyl)sulfanyl-1-[(9,10-dioxo-2-anthryl)methyl]-5-isopropyl-pyrimidine-2,4-dione

HRID 1611348Notes

Reaction equation

HRID 1611348 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[S:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Cl[CH2:22][C:23]1[CH:36]=[CH:35][C:34]2[C:33](=[O:37])[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[C:26](=[O:38])[C:25]=2[CH:24]=1>>[CH:24]1[C:25]2[C:26](=[O:38])[C:27]3[C:32](=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:33](=[O:37])[C:34]=2[CH:35]=[CH:36][C:23]=1[CH2:22][N:8]1[C:9]([S:10][C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]1=[O:19]

Participants

3

Reactant 2

HCID 3443112-(Chloromethyl)anthraquinoneHCID 104937275-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

Product 1

HCID 159577806-(3,5-Dimethylphenyl)sulfanyl-1-[(9,10-dioxo-2-anthryl)methyl]-5-isopropyl-pyrimidine-2,4-dioneYield 32.2%

Procedure

5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2-chloromethyl anthraquinone were reacted by the same way with the example 1 to obtain the titled compound (165 mg, yield: 32.2%).

Sources & evidence

ORD record
ord-8acf8bf555884ac68292555536c2f908
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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