Picolyl chloride → 1-(Pyridin-2-ylmethyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

HRID 1611354Notes

Reaction equation

HRID 1611354 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[S:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27]Cl>>[N:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[CH2:27][N:8]1[C:9]([S:10][C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]1=[O:19]

Participants

3

Reactant 2

HCID 23393Picolyl chlorideHCID 104937275-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione

Product 1

HCID 159577861-(Pyridin-2-ylmethyl)-5-isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedioneYield 29.4%

Procedure

5-Isopropyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 2-picolyl chloride were reacted by the same way with the example 1 to obtain the titled compound (112 mg, yield: 29.4%).

Sources & evidence

ORD record
ord-10625dc6889c4e66b0ab790304115ecb
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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