3-(Chloromethyl)pyridine → 6-(3,5-Dimethylphenyl)sulfanyl-5-ethyl-1-(3-pyridylmethyl)pyrimidine-2,4-dione

HRID 1611358Notes

Reaction equation

HRID 1611358 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[S:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26]Cl)[CH:21]=1>>[N:20]1[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][N:7]2[C:8]([S:9][C:10]3[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=3)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]2=[O:18])[CH:21]=1

Participants

3

Reactant 2

HCID 183583-(Chloromethyl)pyridineHCID 104927276-(3,5-dimethylphenyl)sulfanyl-5-ethyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159577896-(3,5-Dimethylphenyl)sulfanyl-5-ethyl-1-(3-pyridylmethyl)pyrimidine-2,4-dioneYield 25.9%

Procedure

5-Ethyl-6-(3,5-dimethylphenyl)thio-2,4-pyrimidinedione and 3-picolyl chloride were reacted by the same way with the example 1 to obtain the titled compound (95 mg, yield: 25.9%).

Sources & evidence

ORD record
ord-02d27af360654423a6db318140a3de55
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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