2-(Chloromethyl)quinoline → 6-(3,5-Dimethylphenoxy)-5-isopropyl-1-(2-quinolylmethyl)pyrimidine-2,4-dione

HRID 1611366Notes

Reaction equation

HRID 1611366 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[O:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Cl[CH2:22][C:23]1[CH:32]=[CH:31][C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[N:24]=1>>[N:24]1[C:25]2[C:30](=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:31]=[CH:32][C:23]=1[CH2:22][N:8]1[C:9]([O:10][C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]1=[O:19]

Participants

3

Reactant 2

HCID 203942-(Chloromethyl)quinolineHCID 222565785-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159578066-(3,5-Dimethylphenoxy)-5-isopropyl-1-(2-quinolylmethyl)pyrimidine-2,4-dioneYield 33.5%

Procedure

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2-chloromethyl quinoline were reacted by the same way with the example 1 to obtain the titled compound (139 mg, yield: 33.5%).

Sources & evidence

ORD record
ord-6c723a23578442bab135b42173d8ca19
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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