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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1611366Generated: October 29, 2026

2-(Chloromethyl)quinoline → 6-(3,5-Dimethylphenoxy)-5-isopropyl-1-(2-quinolylmethyl)pyrimidine-2,4-dione

https://huagongshe.com/reaction/1611366

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Chloromethyl)quinolineHCID 20394—
Reactant5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneHCID 22256578—
Product6-(3,5-Dimethylphenoxy)-5-isopropyl-1-(2-quinolylmethyl)pyrimidine-2,4-dioneHCID 1595780633.5%

Reaction Steps

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2-chloromethyl quinoline were reacted by the same way with the example 1 to obtain the titled compound (139 mg, yield: 33.5%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06987114B1
Source datasetuspto-grants-2006_01
ORD IDord-6c723a23578442bab135b42173d8ca19
Source noteuspto-grants-2006_01