1-(Chloromethyl)-1H-benzotriazole → 1-(1H-benzotriazol-1-ylmethyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 1611374Notes

Reaction equation

HRID 1611374 reaction equation
[CH2:1]([C:3]1[C:4](=[O:19])[NH:5][C:6](=[O:18])[NH:7][C:8]=1[O:9][C:10]1[CH:15]=[C:14]([CH3:16])[CH:13]=[C:12]([CH3:17])[CH:11]=1)[CH3:2].Cl[CH2:21][N:22]1[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[N:24]=[N:23]1>>[N:22]1([CH2:21][N:7]2[C:8]([O:9][C:10]3[CH:11]=[C:12]([CH3:17])[CH:13]=[C:14]([CH3:16])[CH:15]=3)=[C:3]([CH2:1][CH3:2])[C:4](=[O:19])[NH:5][C:6]2=[O:18])[C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[N:24]=[N:23]1

Participants

3

Reactant 2

HCID 33282221-(Chloromethyl)-1H-benzotriazoleHCID 109232665-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159578121-(1H-benzotriazol-1-ylmethyl)-5-ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneYield 28.6%

Procedure

5-Ethyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 1-chloromethyl-1H-benzotriazole were reacted by the same way with the example 1 to obtain the titled compound (112 mg, yield: 28.6%).

Sources & evidence

ORD record
ord-ca05d954af8f40d7bd7d28b39a2cb090
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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