1-(Chloromethyl)-1H-benzotriazole → 1-(Benzotriazol-1-ylmethyl)-6-(3,5-dimethylphenoxy)-5-isopropyl-pyrimidine-2,4-dione

HRID 1611375Notes

Reaction equation

HRID 1611375 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[O:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Cl[CH2:22][N:23]1[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[N:25]=[N:24]1>>[N:23]1([CH2:22][N:8]2[C:9]([O:10][C:11]3[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=3)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]2=[O:19])[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[N:25]=[N:24]1

Participants

3

Reactant 2

HCID 33282221-(Chloromethyl)-1H-benzotriazoleHCID 222565785-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159578131-(Benzotriazol-1-ylmethyl)-6-(3,5-dimethylphenoxy)-5-isopropyl-pyrimidine-2,4-dioneYield 26.6%

Procedure

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 1-chloromethyl-1H-benzotriazole were reacted by the same way with the example 1 to obtain the titled compound (108 mg, yield: 26.6%).

Sources & evidence

ORD record
ord-ecace5818b574cc48e68e250097f8acc
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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