Methyl 2-(Bromomethyl)-3-Furoate → 1-(3-Methoxycarbonyl-2-furanylmethyl)-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

HRID 1611385Notes

Reaction equation

HRID 1611385 reaction equation
[CH:1]([C:4]1[C:5](=[O:20])[NH:6][C:7](=[O:19])[NH:8][C:9]=1[O:10][C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Br[CH2:22][C:23]1[O:24][CH:25]=[CH:26][C:27]=1[C:28]([O:30][CH3:31])=[O:29]>>[CH3:31][O:30][C:28]([C:27]1[CH:26]=[CH:25][O:24][C:23]=1[CH2:22][N:8]1[C:9]([O:10][C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:20])[NH:6][C:7]1=[O:19])=[O:29]

Participants

3

Reactant 2

HCID 2736827Methyl 2-(Bromomethyl)-3-FuroateHCID 222565785-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione

Product 1

HCID 159578221-(3-Methoxycarbonyl-2-furanylmethyl)-5-isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedioneYield 33.5%

Procedure

5-Isopropyl-6-(3,5-dimethylphenoxy)-2,4-pyrimidinedione and 2-bromomethyl-3-methoxycarbonylfurane were reacted by the same way with the example 1 to obtain the titled compound (133 mg, yield: 33.5%).

Sources & evidence

ORD record
ord-d07b54044b5f44c8b285ee18e7de2bce
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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