Methyl 2-(Bromomethyl)-3-Furoate → 1-(3-Methoxycarbonyl-2-furanylmethyl)-5-isopropyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedione

HRID 1611387Notes

Reaction equation

HRID 1611387 reaction equation
[CH:1]([C:4]1[C:5](=[O:21])[NH:6][C:7](=[O:20])[NH:8][C:9]=1[C:10](=[O:19])[C:11]1[CH:16]=[C:15]([CH3:17])[CH:14]=[C:13]([CH3:18])[CH:12]=1)([CH3:3])[CH3:2].Br[CH2:23][C:24]1[O:25][CH:26]=[CH:27][C:28]=1[C:29]([O:31][CH3:32])=[O:30]>>[CH3:32][O:31][C:29]([C:28]1[CH:27]=[CH:26][O:25][C:24]=1[CH2:23][N:8]1[C:9]([C:10](=[O:19])[C:11]2[CH:12]=[C:13]([CH3:18])[CH:14]=[C:15]([CH3:17])[CH:16]=2)=[C:4]([CH:1]([CH3:3])[CH3:2])[C:5](=[O:21])[NH:6][C:7]1=[O:20])=[O:30]

Participants

3

Reactant 2

HCID 2736827Methyl 2-(Bromomethyl)-3-FuroateHCID 222565826-(3,5-Dimethyl-benzoyl)-5-isopropyl-1H-pyrimidine-2,4-dione

Product 1

HCID 159578241-(3-Methoxycarbonyl-2-furanylmethyl)-5-isopropyl-6-(3,5-dimethyl-benzoyl)-2,4-pyrimidinedioneYield 39.7%

Procedure

5-Isopropyl-6-(3,5-dimethylbenzoyl)-2,4-pyrimidinedione and 2-bromomethyl-3-methoxycarbonylfurane were reacted by the same way with the example 1 to obtain the titled compound (162 mg, yield: 39.7%).

Sources & evidence

ORD record
ord-5c428f22f4d24f41a241c41fc4509326
Source dataset
uspto-grants-2006_01
Patent number
US06987114B1

Reaction notes

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