Water → Lenvatinib

HRID 161141Notes

Reaction equation

HRID 161141 reaction equation
[C:1]([NH2:2])(=[O:3])[c:4]1[cH:5][c:6]2[c:7]([O:16][c:17]3[cH:18][c:19]([Cl:33])[c:20]([NH:23][C:24]([O:25][c:27]4[cH:28][cH:29][cH:30][cH:31][cH:32]4)=[O:26])[cH:21][cH:22]3)[cH:8][cH:9][n:10][c:11]2[cH:12][c:13]1[O:14][CH3:15].[CH3:39][N:40]([CH3:41])[CH:42]=[O:43].[CH:34]1([NH2:37])[CH2:35][CH2:36]1.[OH2:38]>>[C:1]([NH2:2])(=[O:3])[c:4]1[cH:5][c:6]2[c:7]([O:16][c:17]3[cH:18][c:19]([Cl:33])[c:20]([NH:23][C:24](=[O:25])[NH:37][CH:34]4[CH2:35][CH2:36]4)[cH:21][cH:22]3)[cH:8][cH:9][n:10][c:11]2[cH:12][c:13]1[O:14][CH3:15]

Participants

5

Reactant 4

HCID 962WaterHCID 6228DimethylformamideHCID 69828CyclopropylamineHCID 22936529(4-((6-(Aminocarbonyl)-7-methoxy-4-quinolinyl)oxy)-2-chlorophenyl)carbamic acid phenyl ester

Product 1

HCID 9823820Lenvatinib

Sources & evidence

ORD record
ord-1dd25f9501f7430eb4166b000d8f01b4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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