HCID 22257126, compound → HCID 22257125, compound

HRID 1611460Notes

Reaction equation

HRID 1611460 reaction equation
[Cl:1][C:2]1[CH:19]=[C:18]([O:20]CC2C=CC=CC=2)[CH:17]=[C:16]([Cl:28])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].[H][H]>[Pd].C(O)C.C(OCC)(=O)C>[Cl:1][C:2]1[CH:19]=[C:18]([OH:20])[CH:17]=[C:16]([Cl:28])[C:3]=1[O:4][CH2:5][CH2:6][CH2:7][NH:8][C:9]([O:11][C:12]([CH3:14])([CH3:15])[CH3:13])=[O:10]

Participants

6

Reactant 2

HCID 22257126HCID 22257126, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 22257125HCID 22257125, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

This compound was prepared in a manner analogous to that of Step A of Example 3, using 4.1 grams (0.0096 mole) of N-{3-[2,6-dichloro-4-(phenylmethoxy)phenoxy]propyl}(tert.-butoxy)carboxamide, a catalytic amount of 10% palladium on carbon and a theoretical amount of hydrogen gas in 60 mL of 1:1 ethanol and ethyl acetate in a Parr Hydrogenator. The yield of the subject compound was 3.5 grams.

Workup

  1. customThis compound was prepared in a manner analogous to that of Step A of Example 3

Sources & evidence

ORD record
ord-8d1f5a4f26c645f1987e8df873c69408
Source dataset
uspto-grants-2006_01
Patent number
US06987194B2

Reaction notes

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