Ammonia → HCID 10453036, compound

HRID 1611682Notes

Reaction equation

HRID 1611682 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[OH:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[N:19]=[C:18](C)[CH:17]=[CH:16]2.[NH3:22]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[C:6]([Cl:8])[CH:7]=1)[O:9][CH2:6][CH2:7][CH2:2][CH:3]([CH3:4])[O:10][C:11]1[CH:12]=[CH:13][CH:14]=[C:15]2[C:20]=1[N:19]=[C:18]([NH2:22])[CH:17]=[CH:16]2

Participants

4

Reactant 3

HCID 222AmmoniaHCID 115713,5-DichlorophenolHCID 132242-Methyl-8-hydroxyquinoline

Product 1

HCID 10453036HCID 10453036, compound

Procedure

The title compound was prepared according to the procedure described in Example 86 substituting 3,5-dichlorophenol for 8-hydroxyquinaldine. 1H NMR (500 MHz, CDCl3) δ ppm 7.96 (d, 1H), 7.32 (t, 1H), 7.21 (dd, 1H), 7.12 (m, 1H), 6.99 (d, 1H), 6.84 (m, 1H), 6.64 (m, 2H), 4.68 (m, 1H), 4.05 (m, 1H), 3.95 (m, 1H), 2.18 (m, 1H), 2.00 (m, 3H), 1.47 (d, 3H); MS (DCI/NH3) m/z 391 [M+H]+.

Sources & evidence

ORD record
ord-16f5166016134e259f6485241b5f4b00
Source dataset
uspto-grants-2006_01
Patent number
US06989392B2

Reaction notes

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