Ammonia → HCID 10360329, compound

HRID 1611686Notes

Reaction equation

HRID 1611686 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[OH:10][C:11]1[CH:12]=[C:13]([CH:18]=[CH:19][CH:20]=1)[C:14](OC)=O.[NH3:21]>>[NH2:21][C:4]1[CH:3]=[CH:14][C:13]2[C:12](=[C:11]([O:10][CH:7]([CH3:6])[CH2:8][CH2:9][CH2:2][O:1][C:2]3[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=3[C:4]#[N:5])[CH:20]=[CH:19][CH:18]=2)[N:5]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 119072-HydroxybenzonitrileHCID 88068Methyl 3-Hydroxybenzoate

Product 1

HCID 10360329HCID 10360329, compound

Procedure

The title compound was prepared according to the procedure described in Example 92 substituting 2-hydroxybenzonitrile for methyl 3-hydroxybenzoate. 1H NMR (500 MHz, CDCl3) δ ppm 7.94 (d, 1H), 7.46 (m, 2H), 7.33 (t, 1H), 7.20 (m, 2H), 6.96 (m, 2H), 6.91 (m, 1H), 4.78 (m, 1H), 4.22 (m, 1H), 4.12 (m, 1H), 2.23 (m, 1H), 1.96–2.18 (m, 3H), 1.47 (d, 3H); MS (DCI/NH3) m/z 348 [M+H]+.

Sources & evidence

ORD record
ord-aa3c767d6d27498f92a765a2f5fe68f3
Source dataset
uspto-grants-2006_01
Patent number
US06989392B2

Reaction notes

Loading…