Ammonia → 8-(4-(3-Anilinophenoxy)-1-methylbutoxy)quinolin-2-amine

HRID 1611689Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1611689
[NH:1]([C:8]1[CH:9]=[C:10]([OH:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH:15][C:16]1[CH:17]=[C:18]([CH:23]=[CH:24][CH:25]=1)[C:19](OC)=O.[NH3:26]>>[NH:1]([C:8]1[CH:9]=[C:10]([CH:11]=[CH:12][CH:13]=1)[O:14][CH2:12][CH2:13][CH2:8][CH:9]([CH3:10])[O:15][C:16]1[CH:25]=[CH:24][CH:23]=[C:18]2[C:17]=1[N:26]=[C:2]([NH2:1])[CH:3]=[CH:19]2)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 222AmmoniaHCID 75463-Hydroxy-N-phenylanilineHCID 88068Methyl 3-Hydroxybenzoate

Produkt 1

HCID 100703478-(4-(3-Anilinophenoxy)-1-methylbutoxy)quinolin-2-amine

Versuchsvorschrift

The title compound was prepared according to the procedure described in Example 92 substituting 3-anilinophenol for methyl 3-hydroxybenzoate. 1H NMR (500 MHz, CDCl3) δ ppm 7.91 (d, 1H), 7.26 (m, 3H), 7.16 (m, 1H), 7.12 (m, 1H), 7.07 (m, 3H), 6.94 (d, 1H), 6.91 (m, 1H), 6.60 (m, 1H), 6.52 (t, 1H), 6.37 (m, 1H), 4.69 (m, 1H), 4.03 (m, 1H), 3.96 (m, 1H), 2.18 (m, 1H), 1.96 (m, 3H), 1.46 (d, 3H); MS (DCI/NH3) m/z 414 [M+H]+.

Quellen und Nachweise

ORD-Eintrag
ord-eecabcd3960d48c794ad8350cd4139cf
Quelldatensatz
uspto-grants-2006_01
Patentnummer
US06989392B2

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