Ammonia → HCID 22254601, compound

HRID 1611695Notes

Reaction equation

HRID 1611695 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1)#[N:2].[OH:10][C:11]1[CH:12]=[C:13]([CH:18]=[CH:19][CH:20]=1)[C:14](OC)=O.[NH3:21]>>[NH2:21][C:1]1[CH:3]=[CH:14][C:13]2[C:12](=[C:11]([O:10][CH:5]([CH3:4])[CH2:6][CH2:7][CH2:8][O:9][C:5]3[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=3)[C:1]#[N:2])[CH:20]=[CH:19][CH:18]=2)[N:2]=1

Participants

4

Reactant 3

HCID 222AmmoniaHCID 133943-CyanophenolHCID 88068Methyl 3-Hydroxybenzoate

Product 1

HCID 22254601HCID 22254601, compound

Procedure

The title compound was prepared according to the procedure described in Example 92 substituting 3-cyanophenol for methyl 3-hydroxybenzoate. 1H NMR (500 MHz, DMSO-d6) δ ppm 8.36 (d, 1H), 7.47 (m, 2H), 7.42 (m, 2H), 7.35 (m, 1H), 7.31 (m, 1H), 7.20 (m, 1H), 7.12 (d, 1H), 4.87 (m, 1H), 4.10 (m, 2H), 1.78–2.07 (m, 4H), 1.40 (d, 3H); MS (DCI/NH3) m/z 348 [M+H]+.

Sources & evidence

ORD record
ord-6b1e64f8b3024d9885664ab78d59612e
Source dataset
uspto-grants-2006_01
Patent number
US06989392B2

Reaction notes

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