Sulfamide → HCID 22255783, compound

HRID 1611851Notes

Reaction equation

HRID 1611851 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([O:18]C)=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5](O)=[O:6].[S:24]([NH2:28])([NH2:27])(=[O:26])=[O:25]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Br:23])[C:10]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:13]=1)[C:5]([NH:27][S:24]([NH2:28])(=[O:26])=[O:25])=[O:6]

Participants

3

Reactant 2

HCID 82267SulfamideHCID 11015728HCID 11015728, compound

Product 1

HCID 22255783HCID 22255783, compoundYield 73.1%

Procedure

3,5-Dibromo-4-(4-methoxy-3-isopropylphenoxy)benzoic acid (0.035 mmol) was coupled with sulfamide (0.175 mmol) using the method described in Example 58. Purification on HPLC of the residue gave 13 mg (73%) of the title compound.

Workup

  1. customPurification on HPLC of the residue

Sources & evidence

ORD record
ord-93ce07c656c2463ca186a944bd7b5824
Source dataset
uspto-grants-2006_01
Patent number
US06989402B1

Reaction notes

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