Bullatacin → HCID 131725266, compound

HRID 1611922Notes

Reaction equation

HRID 1611922 reaction equation
[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C@H:11]([OH:44])[C@@H:12]1[O:16][C@@H:15]([C@@H:17]2[O:21][C@@H:20]([C@H:22]([OH:43])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][C@@H:33](O)[CH2:34][C:35]3[C:39](=[O:40])[O:38][C@@H:37]([CH3:41])[CH:36]=3)[CH2:19][CH2:18]2)[CH2:14][CH2:13]1>CO>[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C@H:11]([OH:44])[C@@H:12]1[O:16][C@@H:15]([C@@H:17]2[O:21][C@@H:20]([C@H:22]([OH:43])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]3[C:39](=[O:40])[O:38][C@@H:37]([CH3:41])[CH:36]=3)[CH2:19][CH2:18]2)[CH2:14][CH2:13]1.[CH3:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH:11]([OH:44])[CH:12]1[O:16][CH:15]([CH:17]2[O:21][CH:20]([CH:22]([OH:43])[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][C:35]3[C:39](=[O:40])[O:38][CH:37]([CH3:41])[CH:36]=3)[CH2:19][CH2:18]2)[CH2:14][CH2:13]1

Participants

3

Reactant 1

HCID 11124994Bullatacin

Product 1

HCID 131725266HCID 131725266, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Insect antifeedant bioassay of squamocin-G and isosquamocin were found to be toxic to the first and third instar larvae of origental armyworm (Mythimna separata WLK) at a concentration of 10.05% (MeOH) at 27° causing 70% mortality compared to 7% mortality of untreated control. The sample solutions (10 μl of a 0.05% solution) were applied evenly to the lower surface of leaf discs (5 cm2) cut from sorghum hybrid variety CSH5 and the discs were allowed to dry on filter papers. After drying the leaf, discs were offered to 10 first instar M. separata larvae in plastic cups or to one third instar larva in 9-cm (diameter) plastic petric dishes. All larvae were starved for 2 h before the test and the leaf and the leaf discs were kept on moisture filter papers to keep them turgid. The larvae were confined to leaf discs for 24 h and during the period the larvae scratched or consumed >80% of the leaf disc area in the untreated controls. The leaf discs were rated visually for the extent of feeding on a scale upto 1 to 9 (1=<10%, 2=11 to 20%, 3=21 to 30%, 4=31 to 40%, 5=41 to 7=61 to 70%, 8=71 to 80%, 9=>80% leaf area scratched consumed). The larvae were then stirred for 12 h and weighed. Isosquamocin was evaluated by this procedure and the results have shown that it drastically. The feeding of the leaves of sorghum hybrid variety CSH 5 at a concentration of 0.05% in methanol) in comparison with control (methanol) against the first instar and third instar larvae of oriental armyworm (Mythimna separata WLK). It is very toxic to first instar larvae causing high larval mortality and the results are presented below:

Workup

  1. customat 27°
  2. customto dry
  3. filtrationon filter papers
  4. customAfter drying the leaf, discs
  5. filtrationon moisture filter papers
  6. waitThe larvae were confined to leaf discs for 24 h and during the period
  7. customconsumed >80% of the leaf disc area in the untreated controls
  8. customof feeding on a scale upto 1 to 9 (1=<10%, 2=11 to 20%, 3=21 to 30%, 4=31 to 40%, 5=41 to 7=61 to 70%, 8=71 to 80%, 9=>80% leaf area scratched consumed)

Sources & evidence

ORD record
ord-1f9ae0c6cb944d48b7080537d4607c24
Source dataset
uspto-grants-2006_01
Patent number
US06991818B2

Reaction notes

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